Identification of SQ609 as a lead compound from a library of dipiperidines

…, G De los Santos, V Reddy, P Chen, F Barbosa…

Index: Bogatcheva, Elena; Hanrahan, Colleen; Nikonenko, Boris; De Los Santos, Gladys; Reddy, Venkata; Chen, Ping; Barbosa, Francis; Einck, Leo; Nacy, Carol; Protopopova, Marina Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 18 p. 5353 - 5357

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Citation Number: 37

Abstract

We recently reported that compounds created around a dipiperidine scaffold demonstrated activity against Mycobacterium tuberculosis (Mtb)(Bogatcheva, E.; Hanrahan, C.; Chen, P.; Gearhart, J.; Sacksteder, K.; Einck, L.; Nacy, C.; Protopopova, M. Bioorg. Med. Chem. Lett. 2010, 20, 201). To optimize the dipiperidine compound series and to select a lead compound to advance into preclinical studies, we evaluated the structure–activity ...