Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into …

S Zhai, L Yang, QC Cui, Y Sun, QP Dou…

Index: Zhai, Shumei; Yang, Lei; Cui, Qiuzhi Cindy; Sun, Ying; Dou, Q. Ping; Yan, Bing Journal of Biological Inorganic Chemistry, 2010 , vol. 15, # 2 p. 259 - 269

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Citation Number: 75

Abstract

Abstract We have previously reported that when mixed with copper, 8-hydroxyquinoline (8- OHQ) and its analog clioquinol (CQ) inhibited the proteasomal activity and proliferation in cultured human cancer cells. CQ treatment of high-copper-containing human tumor xenografts also caused cancer suppression, associated with proteasome inhibition in vivo. However, the nature of the copper dependence of these events has not been elucidated ...