Synthesis

Convenient N-formylation of secondary amines: KF-Al2O3-promoted synthesis of formamide derivatives via dichlorocarbene generated from chloroform

M Mihara, Y Ishino, S Minakata, M Komatsu

Index: Mihara, Masatoshi; Ishino, Yoshio; Minakata, Satoshi; Komatsu, Mitsuo Synthesis, 2003 , # 15 p. 2317 - 2320

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Citation Number: 46

Abstract

Abstract The treatment of secondary amines with chloroform in the presence of KF-Al 2 O 3 in acetonitrile brought about highly facile and efficient N-formylation to give the corresponding formamides in good to excellent yields. The N-formylation reaction not only involves mild conditions, simple operations and high yields but high chemoselectivity as well.