aC-Acylamino acid esters (3-oxo-2-amino acid esters, 6) were prepared in good yields by the acid hydrolysis of a-acyl-a-isocyanoacetate analogs (5) and oxazole-4-carboxylate derivatives (4), which were easily obtained by the reaction cf a-isocyanoacetate analogs (1) with acyl halides (2) or acid anhydrides (3) in the presence of metallic or organic bases. Further, the hydrolysis of 6 and 4 gave the a-amino ketones (7) in high yields.
