The Journal of Organic Chemistry

[18O] Chiral phosphate in d (CpA) and d (TpA): synthesis via phosphate triesters and assignment of configuration

W Herdering, F Seela

Index: Herdering, Wilhelm; Seela, Frank Journal of Organic Chemistry, 1985 , vol. 50, # 25 p. 5314 - 5323

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Citation Number: 13

Abstract

The dinucleoside monophosphates d (TpA)(lla) and d (CpA)(19a)-both chirally labeled with'80 at phosphorus and representing cleavage sites in a number of restriction endonuclease recognition sequences-have been synthesized via the fully proteded phosphate triesters 8a/b and 16a/b. The latter were obtained from condensation of the pyrimidine phosphoramidites 3a/b and 5a/b with an appropriately protected adenosine ...