In an effort to develop new types of antiulcer agents, a series of novel 3 (2H)-pyridazinone derivatives and related analogues was synthesized. Substituted 3 (2H)-pyridazinones and their 4, bdihydro analogues were alkylated by w-haloalkyl cyanides at the N-2 position under phase-transfer catalytic reaction, and the nitrile group was converted to the thio amide group by treatment with hydrogen sulfide alone or with the appropriate primary or ...
[Merchant, J. R.; Kulkarni, S. D.; Venkatesh, M. S. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 10 p. 914 - 916]
