Highly selective adenosine A2 receptor agonists in a series of N-alkylated 2-aminoadenosines

…, GR Ghai, AJ Hutchison, MA Moskal…

Index: Francis, John E.; Webb, Randy L.; Ghai, Geetha R.; Hutchison, Alan J.; Moskal, Michael A.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2570 - 2579

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Citation Number: 69

Abstract

A wide variety of 2-substituted aminoadenosines were prepared for comparison with the moderately A2 receptor selective adenosine agonist 2-anilinoadenosine (CV-1808). High selectivity combined with significant affinity at the A2 receptor in rat membranes was observed for those amines bearing a two-carbon chain to which was attached an aryl, heteroaryl, or alicyclic moiety. 2-(2-Phenethylamino) adenosine (3d), a 14-fold A2 ...