Tetrahedron letters

A concise synthesis of ortho-substituted aryl-acrylamides—potent activators of soluble guanylyl cyclase

HQ Zhang, Z Xia, T Kolasa, J Dinges

Index: Zhang, Henry Q.; Xia, Zhiren; Kolasa, Teodozyj; Dinges, Jurgen Tetrahedron Letters, 2003 , vol. 44, # 48 p. 8661 - 8663

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Citation Number: 14

Abstract

Horner–Emmons reaction of phosphonate amides with aldehydes leads to generation of o- substituted aryl-acrylamides. These compounds have been shown to be useful to quickly establish structure–activity relationships (SAR) for soluble guanylyl cyclase (sGC) activator drug discovery.