α-Halogenation of carbonyl compounds: halotrimethylsilane–nitrate salt couple as an efficient halogenating reagent system

GKS Prakash, R Ismail, J Garcia, C Panja, G Rasul…

Index: Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A. Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221

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Citation Number: 18

Abstract

The conversion of C–H bonds to C–X bonds (X = F, Cl, Br and I) has a variety of applications in medicinal chemistry. The C–X bonds can alter the metabolic activity as well as bioavailability significantly. 1 α-Halogenated carbonyl compounds are important synthetic intermediates and are used as precursors for various organic transformations. 2 α-Haloacetophenone derivatives, particularly the bromo analogs, have been investigated for their active ...