In vitro and in vivo biological evaluation of new 4, 5-disubstituted 1, 2, 3-triazoles as cis-constrained analogs of combretastatin A4

…, L Quentin, D Scherman, S Bourg, D Dauzonne

Index: Mur Blanch, Nuria; Chabot, Guy G.; Quentin, Lionel; Scherman, Daniel; Bourg, Stephane; Dauzonne, Daniel European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 22 - 32

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Citation Number: 25

Abstract

To find new and better antivascular agents for cancer therapy, a series of combretastatin A4 (CA4) analogs were prepared from 1, 3-diaryl-2-nitroprop-1-enes (6–12) obtained in a two- step synthesis from appropriate arylaldehydes and 2-aryl-1-nitroethanes (4 or 5). Treatment of these 1, 3-diaryl-2-nitroprop-1-enes 6–12 by sodium azide in DMSO yielded the targeted compounds. The synthesized 1, 2, 3-triazoles disubstituted in 4-and 5-positions by one ...