Design and synthesis of novel 3-(benzo [d] oxazol-2-yl)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) pyridin-2-amine derivatives as selective G-protein-coupled receptor …

…, H Jung, CS Yun, J Du Ha, HR Kim, CH Chae…

Index: Cho, Sung Yun; Lee, Byung Ho; Jung, Heejung; Yun, Chang Soo; Ha, Jae Du; Kim, Hyoung Rae; Chae, Chong Hak; Lee, Jeong Hyun; Seo, Ho Won; Oh, Kwang-Seok Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6711 - 6716

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Citation Number: 7

Abstract

Abstract G-protein-coupled receptor kinase (GRK)-2 and-5 are emerging therapeutic targets for the treatment of cardiovascular disease. In our efforts to discover novel small molecules to inhibit GRK-2 and-5, a class of compound based on 3-(benzo [d] oxazol-2-yl)-5-(1- (piperidin-4-yl)-1H-pyrazol-4-yl) pyridin-2-amine was identified as a novel hit by high throughput screening campaign. Structural modification of parent benzoxazole scaffolds ...