Journal of Fluorine Chemistry

… fluorination of hexahydroazepine, methylpiperidines and methyl 1-hexahydroazepine-acetate: the preparation of F-(1-hexahydroazepine-acetyl fluoride) and its …

T Abe, SK Pandey, H Baba

Index: Abe, Takashi; Pandey, Sushil K.; Baba, Hajime Journal of Fluorine Chemistry, 2000 , vol. 105, # 1 p. 149 - 157

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Citation Number: 5

Abstract

The electrochemical fluorination of hexahydroazepine (1), methylpiperidines (2)[2- methylpiperidine (2a), 3-methylpiperidine (2b), 4-methylpiperidine (2c)] and methyl 1- hexahydroazepine-acetate (3) was examined. An extensive cleavage of the C–N bond occurred in the fluorination of secondary cyclic amines (1, 2a–c) resulting in only a small yield of the corresponding F-(N-fluoro cyclic amines). F-(1-hexahydroazepine-acetyl ...