Abstract Highly regioselective reaction of some substituted 2, 4-dichloroquinolines with symmetrical 1, 4-dihydropyridines, leading to novel quinoline derivatives of DHPs, has been achieved in the presence of powdered K 2 CO 3, as a mild and efficient base, at moderate temperature. All the synthesized compounds were characterized by use of IR, NMR, and mass spectral data.