Organic letters

Titanocene (III)-promoted Reformatsky additions

JD Parrish, DR Shelton, RD Little

Index: Parrish; Shelton, Daniel R.; Little, R. Daniel Organic Letters, 2003 , vol. 5, # 20 p. 3615 - 3617

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Citation Number: 53

Abstract

A novel method for the promotion of Reformatsky-like reactions is presented. The technique employs titanocene (III) chloride as a mild and homogeneous single-electron reductant. The reactions are rapid, operationally simple, and compatible with a wide range of functionalities. These additions are also anti diastereoselective.