Synthesis of 4??Substituted Piperidines via a Mild and Scalable Two??Step Cu2O??Mediated Decarboxylation of Cyanoesters

…, WM Kazmierski, CS Koble, JB Thompson…

Index: Chauder, Brian A.; Boros, Eric E.; Du, Kien S.; Kazmierski, Wieslaw M.; Koble, Cecilia S.; Thompson, James B.; Tabet, Elie A. Synthetic Communications, 2006 , vol. 36, # 3 p. 279 - 284

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Citation Number: 6

Abstract

Abstract A four??step, high??yielding, kilogram??scale protocol to prepare aldehyde 5 is reported. The key reaction is a mild, two??step Cu2O??mediated decarboxylation of cyanoester 3 that proceeds in excellent yield. The general applicability of this methodology has also been explored.