Tetrahedron

Chemoselective Heck arylation of acrolein diethyl acetal catalyzed by an oxime-derived palladacycle

C Nájera, L Botella

Index: Najera, Carmen; Botella, Luis Tetrahedron, 2005 , vol. 61, # 41 p. 9688 - 9695

Full Text: HTML

Citation Number: 23

Abstract

A dimeric 4-hydroxyacetophenone oxime-derived palladacycle has been used as a very efficient precatalyst for the chemoselective arylation of acrolein diethyl acetal to give either cinnamaldehyde derivatives or 3-arylpropanoate esters by proper choice of the reaction conditions. The synthesis of cinnamaldehyde derivatives can be performed by Heck reaction of acrolein diethyl acetal with iodo-, bromo-or chloroarenes in N, N-dimethylacetamide ( ...