Novel CCR1 antagonists with improved metabolic stability

…, WH Brissette, JH Chang, K Colizza, M Conklyn…

Index: Brown, Matthew F.; Avery, Mike; Brissette, William H.; Chang; Colizza, Kevin; Conklyn, Maryrose; DiRico, Amy P.; Gladue, Ronald P.; Kath, John C.; Krueger, Suzanne S.; Lira, Paul D.; Lillie, Brett M.; Lundquist, Greg D.; Mairs, Erin N.; McElroy, Eric B.; McGlynn, Molly A.; Paradis, Timothy J.; Poss, Christopher S.; Rossulek, Michelle I.; Shepard, Richard M.; Sims, Jeff; Strelevitz, Timothy J.; Truesdell, Susan; Tylaska, Laurie A.; Yoon, Kwansik; Zheng, Deye Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 9 p. 2175 - 2179

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Citation Number: 26

Abstract

... Table 2. Compound, Species, (%) F, Cl p (mL/min/kg), V dss (L/kg), T 1/2 (h), Aqueous solubility (μg/mL). 6c, Dog, 1.6, 12, 1.2, 1.0, ND. Monkey, 2.9, 18, 1.2, 1.2. ... Med. Chem. Lett. (2004) preceding manuscript #1. doi:10.1016/j.bmcl.2004.02.020. [7]; JC Kath, WH Brissette, MF Brown, M Conklyn, AP DiRico, P Dorff, RP Gladue, BM Lillie, PD Lira, EN Mairs, WH Martin, EB McElroy, MA McGlynn, TJ Paradis, CS Poss, IA Stock, LA Tylaska, D Zheng; Bioorg. Med. Chem ...