Interaction of chiral MS-245 analogs at h5-HT 6 receptors

C Abate, R Kolanos, M Dukat, V Setola, BL Roth…

Index: Abate, Carmen; Kolanos, Renata; Dukat, Malgorzata; Setola, Vince; Roth, Bryan L.; Glennon, Richard A. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 15 p. 3510 - 3513

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Citation Number: 21

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Optically active pyrrolidinylmethylindole analogs related in structure to the benzenesulfonyltryptamine 5-HT 6 receptor antagonist MS-245 were evaluated and their R-isomers were found to bind with affinity higher than their S-enantiomers. ... Chiral analogs of the 5-HT 6 ligand MS-245 (K ...