Tetrahedron letters

An efficient access to (R)-and (S)-6, 6′-dimethoxy-2, 2′-diiodo-1, 1′-biphenyl

M Cereghetti, R Schmid, P Schönholzer, A Rageot

Index: Cereghetti, Marco; Schmid, Rudolf; Schoenholzer, Peter; Rageot, Alain Tetrahedron Letters, 1996 , vol. 37, # 30 p. 5343 - 5346

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Citation Number: 14

Abstract

In a better procedure than the known for (rac)-2a, the diamine (rac)-2b was resolved for the first time with the new resolving agent (R, R)-and (S, S)-2, 3-di (phenylamino-carbonyl) tartaric acid (5c)(40–45% weight yields;> 99% ee). The diamines (R)-or (S)-2a and 2b were converted with> 98% stereochemical retention into the diiodides (R)-and (S)-3a and 3b and subsequently, without loss of optical purity, diphenylphosphinated to the known ...