Synthesis of 3, 3′-Di-O-methyl Ardimerin and Exploration of Its DNA Binding Properties

…, K Ng, H Panesar, A Yepremyan, TG Minehan

Index: Yepremyan, Akop; Minehan, Thomas G. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 27 p. 5194 - 5196

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Citation Number: 5

Abstract

The 3, 3′-di-O-methyl derivative (15) of the bis-C-aryl glycoside natural product ardimerin (1) has been synthesized in 11 steps from 2, 3, 4, 6-tetrabenzylglucose (2) and 1, 2, 3- trimethoxybenzene (3). Key steps in the synthesis involve a Lewis acid mediated Friedel–