e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Preparation, fluorination and synthetic utility of a CFC-olefin adduct
M Van Der Puy, TR Demmin, GVB Madhavan…
Index: Van Der Puy, Michael; Demmin, Timothy R.; Bindu Madhavan; Thenappan, Alagappan; Tung, Harry S. Journal of Fluorine Chemistry, 1996 , vol. 76, # 1 p. 49 - 54
1, 1, 1-Trichlorotrifluoroethane was added to ethylene using the catalyst system Fe/triethylphosphite, which eliminated the need for a solvent and avoided the corrosion problems inherent in CuCl-catalyzed reactions. The adduct, CF3CCl2CH2CH2Cl, was fluorinated with HF over a chromium (III) oxide catalyst. A series of alternating dehydrochlorinations and HF additions to internal C= C double bonds was proposed and ...