Asian Journal of Chemistry

Synthesis and Evaluation of Some 2-[(Substituted) ethanoyl] amino-5-aryl-1, 3, 4-thiadiazoles as Diuretic Agents

SK Jain, P Mishra

Index: Jain, Sanmati K.; Mishra, Pradeep Asian Journal of Chemistry, 2011 , vol. 23, # 3 p. 1305 - 1308

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Citation Number: 5

Abstract

Abstract Twelve 2-[(substituted) ethanoyl] amino-5-aryl-1, 3, 4-thiadiazoles were prepared by the reaction of 2-(chloro ethanoyl) amino-5-aryl-1, 3, 4-thiadiazoles and various secondary amines. These compounds were screened for diuretic activity. The compounds namely 4a1, 4b2 and 4c2 showed good diuretic activity comparable with the standard drug acetazolamide at a dose level of 100 mg/kg, orally in albino rats.