Piperazine-Based CCR5 Antagonists as HIV-1 Inhibitors. II. Discovery of 1-[(2, 4-Dimethyl-3-pyridinyl) carbonyl]-4-methyl-4-[3 (S)-methyl-4-[1 (S)-[4-(trifluoro-methyl) …

JR Tagat, RW Steensma, SW McCombie…

Index: Journal of Medicinal Chemistry, , vol. 44, # 21 p. 3343 - 3346

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Citation Number: 129

Abstract

... Journal of Medicinal Chemistry. ... 4 Consequently, the goal of discovering an orally active, potent, and selective small molecule CCR5 antagonist has stimulated vigorous research programs at several pharmaceutical companies. ...