Fatty acid hydroxytyrosyl esters: structure/antioxidant activity relationship by ABTS and in cell-culture DCF assays

…, T Gasperi, S Incerpi, A Gambacorta

Index: Gambacorta, Augusto; Tofani, Daniela; Bernini, Roberta; Migliorini, Antonella Journal of Agricultural and Food Chemistry, 2007 , vol. 55, # 9 p. 3386 - 3391

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Citation Number: 36

Abstract

A large series of hydroxytyrosyl esters of C2− C18 fatty acids with increasing lipophilicity was prepared by a new highly efficient method based on acylation of methylorthoformate- protected hydroxytyrosol. All products were tested for relative antioxidant effect using ABTS assays in ethanolic medium and DCF assays in L6 cells. No linear correlation between lipophilicity and antioxidant effect was found. ABTS assays showed a growing antioxidant ...