Benzofurans are very important compounds due to their broad spectrum of biological and pharmacological effects. Benzofurans are considered as non-steroidal anti-inflammatory drugs [1], COX-2 inhibitor; in addition, diverse pharmacological properties have been associated with benzofuran derivatives [2]. Moreover, phosphodiesterase inhibitory activity, analgesic, antimicrobial, bacteriostatic, bacteriocidal, fungicidal, anticancer, anti-HIV and more has been exhibited ...