The diastereoselective reduction of (R)-N-(tert-butanesulfinyl) ketimines by a ruthenium- catalyzed asymmetric transfer hydrogenation process in isopropyl alcohol, followed by desulfinylation of the nitrogen atom, is an excellent method to prepare highly enantiomerically enriched α-branched primary amines (up to> 99% ee) in short reaction times (1− 4 h).(1 S, 2 R)-1-Amino-2-indanol has been shown to be a very efficient ligand to ...
