BACE-1 has been shown to be an attractive therapeutic target in Alzheimer's disease (AD). Using a 1, 4-dihydropyridine (DHP) scaffold, we synthesized new inhibitors of BACE-1 by modifying the known BACE inhibitor 2 containing a hydroxyethylamine (HEA) motif. Using structure-based drug design based on computer-aided molecular docking, the isophthalamide ring of 2 was replaced with a 1, 4-dihydropyridine ring as a brain-targeting ...
