Abstract New isoelectronic, non-isosteric phosphonate analogues of nucleoside 5′- phosphates featuring the phosphorus moiety directly attached on the sugar ring in the C4′ position are described. The analogues were synthesised by a nucleosidation reaction from tetrofuranosyl phosphonate synthons and silylated nucleobases. The pyrimidine compounds with erythro and threo configuration in both D-and L-series were prepared, and the ...
