In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives

…, KM Hosamani, HR Seetharamareddy

Index: Achar, Kavitha C.S.; Hosamani, Kallappa M.; Seetharamareddy, Harisha R. European Journal of Medicinal Chemistry, 2010 , vol. 45, # 5 p. 2048 - 2054

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Citation Number: 141

Abstract

A series of 2-methylaminobenzimidazole derivatives (1–11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti- inflammatory activities on acetic acid induced writhing in mice and carrageenan induced ...