Synthesis and structure–activity relationships of new antimicrobial active multisubstituted benzazole derivatives

I Yildiz-Oren, I Yalcin, E Aki-Sener…

Index: Yildiz-Oren, Ilkay; Yalcin, Ismail; Aki-Sener, Esin; Ucarturk, Nejat European Journal of Medicinal Chemistry, 2004 , vol. 39, # 3 p. 291 - 298

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Citation Number: 232

Abstract

A series of multisubstituted benzoxazoles, benzimidazoles, and benzothiazoles (5–7) as non-nucleoside fused isosteric heterocyclic compounds was synthesized and tested for their antibacterial activities against various Gram-positive and Gram-negative bacteria and antifungal activity against the fungus Candida albicans. Microbiological results indicated that the synthesized compounds possessed a broad spectrum of activity against the tested ...