Tetrahedron Letters

Regioselectivity in isoquinoline alkaloid synthesis

R Quevedo, E Baquero, M Rodriguez

Index: Quevedo, Rodolfo; Baquero, Edwin; Rodriguez, Mario Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1774 - 1778

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Citation Number: 17

Abstract

Regioselectivity in isoquinoline alkaloid synthesis is analyzed here. Our experiments have shown that substituents on the aromatic ring of the starting amine are determinant in isoquinoline synthesis. The use of dicyclohexylcarbodiimide in activating carboxylic acids for electrophilic aromatic substitution reactions is presented for the first time.