Tetrahedron: Asymmetry

Asymmetric hydrolysis of 2-hydroxy-carboxylic esters using recombinant Escherichia coli

A Nakagawa, K Kato, A Shinmyo, T Suzuki

Index: Nakagawa, Atsushi; Kato, Ko; Shinmyo, Atsuhiko; Suzuki, Toshio Tetrahedron Asymmetry, 2007 , vol. 18, # 20 p. 2394 - 2398

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Citation Number: 9

Abstract

Optically active 2-hydroxy-carboxylates are important compounds for their use as intermediates in the synthesis of pharmaceuticals and stereoblock polymers. Enterobacter sp. DS-S-75 and the recombinant Escherichia coli harbouring the 4-chloro-3- hydroxybutyrate (CHB) hydrolase gene from the strain DS-S-75 showed asymmetric hydrolytic activity towards 2-hydroxy-carboxylates, as well as towards CHB. It was ...