Sequential one-pot bimetallic Ir (III)/Pd (0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1, 3-dimethylbarbituric acid and allenes

…, A Keep, A Derrick, V Sridharan, C Kilner

Index: Loefberg, Christian; Grigg, Ronald; Keep, Ann; Derrick, Andrew; Sridharan, Visuvanathar; Kilner, Colin Chemical Communications, 2006 , # 48 p. 5000 - 5002

Full Text: HTML

Citation Number: 23

Abstract

Microwave assisted indirect functionalization of alcohols with 1, 3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir (III)/Pd (0) catalysed process, involving the formation of three new C–C bonds, one spirocyclic ring and one di-or tri- substituted exocyclic alkene, is described.