e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521

Russian journal of organic chemistry

Solvent-free regioselective synthesis of 6-and 7-substituted pteridines under microwave irradiation

R Singh

Index: Singh; Geetanjali Russian Journal of Organic Chemistry, 2006 , vol. 42, # 1 p. 136 - 138

Full Text: HTML

Citation Number: 2

Abstract

Abstract Reactions of 5, 6-diaminouracils with α-keto aldehydes over acidic and neutral aluminum oxide under microwave irradiation gave the corresponding 6-and 7-substituted 1, 2, 3, 4-tetrahydropteridine-2, 4-diones in 63–79% yield with high regioselectivity.

5,6-DIAMINOPYRIMIDINE-2,4(1H,3H)-DIONE Structure

5,6-DIAMINOPYRI...

2-(4-chlorophenyl)-2-oxo-acetaldehyde Structure

2-(4-chlorophen...

~70%

2,4(1H,3H)-Pteridinedione,6-(4-chlorophenyl)- Structure

2,4(1H,3H)-Pter...

5,6-DIAMINOPYRIMIDINE-2,4(1H,3H)-DIONE Structure

5,6-DIAMINOPYRI...

2-(4-chlorophenyl)-2-oxo-acetaldehyde Structure

2-(4-chlorophen...

~75%

7-(4-chlorophenyl)-1H-pteridine-2,4-dione Structure

7-(4-chlorophen...

5,6-DIAMINOPYRIMIDINE-2,4(1H,3H)-DIONE Structure

5,6-DIAMINOPYRI...

Methylglyoxal Structure

~75%

2,4(1H,3H)-Pteridinedione,7-methyl- Structure

2,4(1H,3H)-Pter...

5,6-Diamino-1,3-Dimethyluracil Structure

5,6-Diamino-1,3...

Phenylglyoxal Structure

~72%

1,3-dimethyl-7-phenylpteridine-2,4-dione Structure

1,3-dimethyl-7-...

5,6-Diamino-1,3-Dimethyluracil Structure

5,6-Diamino-1,3...

Methylglyoxal Structure

~69%

2,4(1H,3H)-Pteridinedione,1,3,7-trimethyl- Structure

2,4(1H,3H)-Pter...

5,6-Diamino-1,3-Dimethyluracil Structure

5,6-Diamino-1,3...

2-(4-chlorophenyl)-2-oxo-acetaldehyde Structure

2-(4-chlorophen...

~71%

7-(4-chlorophenyl)-1,3-dimethylpteridine-2,4-dione Structure

7-(4-chlorophen...

5,6-Diamino-1,3-Dimethyluracil Structure

5,6-Diamino-1,3...

Phenylglyoxal Structure

~78%

2,4(1H,3H)-Pteridinedione,1,3-dimethyl-6-phenyl- Structure

2,4(1H,3H)-Pter...