Biological evaluation of donor-acceptor aminonaphthoquinones as antitumor agents

…, K Bettega, RC Pedrosa, PB Calderon, J Verrax

Index: Benites, Julio; Valderrama, Jaime A.; Bettega, Karina; Pedrosa, Rozangela Curi; Calderon, Pedro Buc; Verrax, Julien European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 6052 - 6057

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Citation Number: 54

Abstract

Several members of the phenylamino-1, 4-naphthoquinone series were prepared in order to investigate structure–activity relationships (SAR) and to explore the antitumor effects associated with this scaffold. The cytotoxic effects of the aminoquinones (EC50) against a panel of cancer cell lines (MCF7, DU145 and T24 cells) and healthy fibroblasts (BALB/3T3) were assessed in vitro using the MTT reduction assay 48 h after drug exposure. SAR ...