Synthesis, molecular docking and evaluation of thiazolyl-pyrazoline derivatives containing benzodioxole as potential anticancer agents

HH Wang, KM Qiu, HE Cui, YS Yang, M Xing…

Index: Wang, Hai-Hong; Qiu, Ke-Ming; Cui, Hong-En; Yang, Yu-Shun; Yin-Luo; Xing, Man; Qiu, Xiao-Yang; Bai, Li-Fei; Zhu, Hai-Liang Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 448 - 455

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Citation Number: 19

Abstract

A series of novel thiazolyl-pyrazoline derivatives containing benzodioxole (C1–C20) have been designed and synthesized. Among of the synthesized compounds, 2-(5-(benzo [d][1, 3] dioxol-5-yl)-3-(4-bromophenyl)-4, 5-dihydro-1H-pyrazol-1-yl)-4-(4-bromophenyl) thiazole (C6) displayed the most potent inhibitory activity for HER-2 (IC50= 0.18 μM for HER-2). Antiproliferative assay results indicated that compound C6 owned high antiproliferative ...

 Related Synthetic Route
3,4-Dihydroxybenzaldehyde Structure

139-85-5

3,4-Dihydroxybe...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-fluorophenyl)- Structure

7397-23-1

2-Propen-1-one,...

1,4-Benzodioxane-6-aldehyde Structure

29668-44-8

1,4-Benzodioxan...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-fluorophenyl)- Structure

7397-23-1

2-Propen-1-one,...

3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1-(4-methoxy-phenyl)-propenone Structure

64376-20-1

3-(2,3-dihydro-...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-fluorophenyl)- Structure

7397-23-1

2-Propen-1-one,...

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide Structure

1417658-61-7

5-(2,3-dihydrob...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-fluorophenyl)- Structure

7397-23-1

2-Propen-1-one,...

1,4-Benzodioxane-6-aldehyde Structure

29668-44-8

1,4-Benzodioxan...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)- Structure

2373-93-5

2-Propen-1-one,...

3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1-(4-methoxy-phenyl)-propenone Structure

64376-20-1

3-(2,3-dihydro-...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)- Structure

2373-93-5

2-Propen-1-one,...

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide Structure

1417658-61-7

5-(2,3-dihydrob...

~%

2-Propen-1-one,3-(1,3-benzodioxol-5-yl)-1-(4-methoxyphenyl)- Structure

2373-93-5

2-Propen-1-one,...

3,4-Dihydroxybenzaldehyde Structure

139-85-5

3,4-Dihydroxybe...

~%

(E)-3-benzo[1,3]dioxol-5-yl-1-(4-methylphenyl)prop-2-en-1-one Structure

37620-38-5

(E)-3-benzo[1,3...

1,4-Benzodioxane-6-aldehyde Structure

29668-44-8

1,4-Benzodioxan...

~%

(E)-3-benzo[1,3]dioxol-5-yl-1-(4-methylphenyl)prop-2-en-1-one Structure

37620-38-5

(E)-3-benzo[1,3...

3-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-1-(4-methoxy-phenyl)-propenone Structure

64376-20-1

3-(2,3-dihydro-...

~%

(E)-3-benzo[1,3]dioxol-5-yl-1-(4-methylphenyl)prop-2-en-1-one Structure

37620-38-5

(E)-3-benzo[1,3...

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide Structure

1417658-61-7

5-(2,3-dihydrob...

~%

(E)-3-benzo[1,3]dioxol-5-yl-1-(4-methylphenyl)prop-2-en-1-one Structure

37620-38-5

(E)-3-benzo[1,3...

5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide Structure

1417658-61-7

5-(2,3-dihydrob...

2,4′-dibromoacetophenone Structure

99-73-0

2,4′-dibromoace...

~80%

piperonal Structure

120-57-0

piperonal


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