Tetrahedron: Asymmetry

Organocatalytic enantioselective synthesis of β-blockers:(S)-propranolol and (S)-naftopidil

SP Panchgalle, RG Gore, SP Chavan…

Index: Panchgalle, Sharad P.; Gore, Rohitkumar G.; Chavan, Subhash P.; Kalkote, Uttam R. Tetrahedron Asymmetry, 2009 , vol. 20, # 15 p. 1767 - 1770

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Citation Number: 24

Abstract

The synthesis of enantiomerically pure bioactive molecules was explored in recent years because (i) biological activity is often associated with only one enantiomer; and (ii) enantiomers may exhibit very different types of activity, both of which may be beneficial or one may be beneficial and the other undesirable. 1 Due to this, the aim for enantiomerically pure molecules has intensified during recent years. ... 1,2-Diols are versatile staring materials for the synthesis of ...