Synthesis of Thiol Esters by the Reaction of Ricinoleic Acid with Thiols Under Solvent-Free Conditions

…, RG Jacob, D Alves, EJ Lenardão, G Perin

Index: Lara, Renata G.; Rodrigues, Dielson C.; Mendes, Samuel R.; Panatieri, Rodrigo B.; Jacob, Raquel G.; Alves, Diego; Lenardao, Eder J.; Perin, Gelson Synthetic Communications, 2011 , vol. 41, # 20 p. 2974 - 2984

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Citation Number: 4

Abstract

Abstract The synthesis of several ricinoleic acid thiol esters starting from cis-(R)-12- hydroxyoctadec-9-enoic acid and thiols in the presence of N, N′-dicyclohexylcarbodiimide (DCC) is described. The method is efficient for aromatic and aliphatic thiols, selectively affording the respective fat acid thiol esters in good yields under mild, neutral, and solvent- free conditions. The protocol is general and was extended to other carboxylic acids, ...