e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Preparation of Various 1, 1-Dihalo-2-haloalkylcyclopropanes and 1, 1, 2-Trihalocyclopropanes and their Reduction to DihaIides using Tributyltin Hydride
The title compounds, most of which were obtained by dihalocarbene addition to the corresponding alkenes, are generally reduced to dihalides in good yields. 1, 1-Dichlor0-2- chloromethyl-2—methylcyclopropane and all the tribromides investigated are attacked regioselectively at the gem-dihalo moiety, yielding isomeric mixtures of 1—halo-2- haloalkylcyclopropanes. Trihalides containing both bromo and chloro substituents are ...
