Tetrahedron

Copper-catalyzed dehydrogenative reaction: synthesis of amide from aldehydes and aminopyridine

S Yang, H Yan, X Ren, X Shi, J Li, Y Wang, G Huang

Index: Yang, Sizhuo; Yan, Hao; Ren, Xiaoyu; Shi, Xiaokang; Li, Jian; Wang, Yuling; Huang, Guosheng Tetrahedron, 2013 , vol. 69, # 31 p. 6431 - 6435

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Citation Number: 21

Abstract

The amide bond is a key functional group in organic chemistry. It plays an important role in the composition of polymers, proteins, natural products, and pharmaceuticals. 1 The most common synthetic route to these nitrogen-containing compounds relies heavily on the reactions of activated carboxylic acids and their derivatives with amines. 2 However, this method has the innate drawbacks, for instance, a large amount of byproducts are generated and the activated ...