Amino acids and peptides. XXII. Synthesis of substrates and inhibitors of human leukocyte cathepsin G.

Y Okada, Y TSUDA, N TENO, Y NAGAMATSU…

Index: Okada; Tsuda; Teno; Nagamatsu; Okamoto Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 12 p. 4794 - 4801

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Citation Number: 4

Abstract

Suc-Tyr-Leu-Phe-pNA is a good substrate for human leukocyte cathepsin G and χ- chymotrypsin but not for human leukocyte elastase (HLE). However, Suc-Tyr-D-Leu-D-Phe- pNA inhibited not only cathepsin G and χ-chymotrypsin but also HLE (K i values, 1.1, 0.94 and 0.16 mM, respectively). The p-nitroanilide (pNA) moiety of Suc-Tyr-Leu-Phe-pNA and Suc-Tyr-D-Leu-D-Phe-pNA was substituted with p-benzoylaniline (BZA), p-acetylaniline ( ...