Synthesis of a new class of uridine phosphorylase inhibitors

…, RP Panzica, FNM Naguib, MH El Kouni

Index: Tzeng, Cherng-Chyi; Panzica, Raymond P.; Naguib, Fardos N.M.; Kouni, Mahmoud H. el Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 5 p. 1399 - 1404

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Citation Number: 30

Abstract

Abstract A new series of potent uridine phosphorylase inhibitors have been prepared from barbituric acid. Among them, 1-[(2-hydroxyethoxy) methyl]-5-)(m--benzyloxy) benzylbarbituric acid (37, BBBA) is the most promising having a K i value of 1.1±0.2 nM with uridine phosphorylase from human liver. The new inhibitors are easily synthesized and are better inhibitors of human uridine phosphorylase than their uracil counterparts.