Stereoselective Synthesis of Optically Active Hydrobenzoins via Asymmetric Hydrogenation of Benzils with Ru (OTf)(TsDPEN)(η6??cymene) as the Pre??catalyst

X Huang, N Li, Z Geng, F Pan…

Index: Huang, Xiaofei; Li, Naikai; Geng, Zhicong; Pan, Fengfeng; Wang, Xingwang Chinese Journal of Chemistry, 2012 , vol. 30, # 11 p. 2657 - 2663

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Citation Number: 5

Abstract

Abstract Optically active hydrobenzoins are very important building blocks for further derivation of biologically active complexes, natural products, and pharmaceutical compounds. In this paper, A practical approach has been developed for asymmetric hydrogenation of benzils with Ru (OTf)(TsDPEN)(η 6-cymene) as a pre-catalyst in methanol. Therefore, a series of chiral hydrobenzoins was synthesized in good yields with good to ...