Catalytic, highly enantio-and diastereoselective pinacol coupling reaction with a new tethered bis (8-quinolinolato) ligand

N Takenaka, G Xia, H Yamamoto

Index: Takenaka, Norito; Xia, Guoyao; Yamamoto, Hisashi Journal of the American Chemical Society, 2004 , vol. 126, # 41 p. 13198 - 13199

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Citation Number: 71

Abstract

A new class of chiral ligand, tethered bis (8-quinolinol)(TBOxH), is developed. Its chromium complex, TBOxCrCl (3 mol%), effectively catalyzes the pinacol coupling reaction of aromatic aldehydes at room temperature with high yield (up to 94%), high diastereoselectivity (up to dl: meso= 98: 2), and high enantioselectivity (up to 98%). The scope of the present method turns out not to be limited to aromatic aldehyde derivatives, as ...