Abstract The first chemical synthesis of the 3-deazaspongosine nucleoside is described, starting from commercially available 4-amino-2, 6-dichloropyridine. The key step is the introduction of required functional groups at the 2 and 6 positions of the 4-amino-3- nitropyridine without any conflict in the synthesis of nucleobase. Regioselective nucleophilic substitution with allyl alkoxide at the 2 position of 4-amino-2, 6-dimethoxypyridine, ...
![2-(5-amino-3-chloro-4,7,9-triazabicyclo[4.3.0]nona-1,3,5,7-tetraen-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Structure](https://image.chemsrc.com/caspic/080/40656-71-1.png)
![4,6-Dichloro-1H-imidazo[4,5-c]pyridine Structure](https://image.chemsrc.com/caspic/493/2589-12-0.png)
![1-(2,3,5-Tri-O-acetyl--D-ribofuranosyl)-4,6-dichloroimidazo[4,5-c]pyridine Structure](https://image.chemsrc.com/caspic/376/63423-94-9.png)