e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Acid-catalyzed cyclization reactions. IX. Formation of oxazolinium and thiazolinium cation from N-allyl and substituted N-allylamides,-urethans,-ureas, and-thioureas
SP McManus, JT Carroll…
Index: McManus,S.P. et al. Journal of Organic Chemistry, 1970 , vol. 35, p. 3768 - 3774
N-Allyl and substituted N-allylamides,-urethans,-ureas, and-thioureas have been cyclized in 60-96% sulfuric acid to their corresponding oxazolinium and thiazolinium cations. By drowning certain of these acid solutions into base, a useful synthetic route to 2-oxazolines and 2-thiazolines has been demonstrated. The formation of oxazolinium (2a-0) and thiazolinium (2p-r) cations was studied by nmr techniques. In general, the simple N-allyl ...
