Abstract The synthesis of 2-chloro-1-(β-D-ribofuranosyl) benzimidazole (4b) has been accomplished by a condensation of 2-chloro-1-trimethylsilylbenzimidazole (1) with 2, 3, 5-tri- O-acetyl-D-ribofuranosyl bromide (2) followed by subsequent deacetylation. Nucleophilic displacement of the 2-chloro group has furnished several interesting 2-substituted-1-(β-D- ribofuranosyl) benzimidazoles. 1-(β-D-Ribofuranosyl) benzimidazole (5) and 1-(β-D- ...
