Synthesis

Efficient copper-catalyzed synthesis of 2-amino-4 (3H)-quinazolinone and 2-aminoquinazoline derivatives

X Huang, H Yang, H Fu, R Qiao, Y Zhao

Index: Huang, Xuhu; Yang, Haijun; Fu, Hua; Qiao, Renzhong; Zhao, Yufen Synthesis, 2009 , # 16 p. 2679 - 2688

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Citation Number: 17

Abstract

Abstract We have developed a versatile and efficient method for copper-catalyzed synthesis of both 2-amino-4 (3H)-quinazolinone and 2-aminoquinazoline derivatives. The protocol uses readily available substituted 2-halobenzoic acids, 2-bromobenzaldehyde, 2- bromophenyl ketones and guanidines as the starting materials, inexpensive copper (I) iodide as the catalyst, and the method has important application values for construction of ...