Enzymatic racemization of amines catalyzed by enantiocomplementary ω??transaminases

D Koszelewski, B Grischek, SM Glueck…

Index: Koszelewski, Dominik; Grischek, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt Chemistry - A European Journal, 2011 , vol. 17, # 1 p. 378 - 383

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Citation Number: 23

Abstract

Abstract A strategy for the biocatalytic racemization of primary α-chiral amines was developed by employing a pair of stereocomplementary PLP-dependent ω-transaminases. The interconversion of amine enantiomers proceeded through reversible transamination by a prochiral ketone intermediate, either catalyzed by a pair of stereocomplementary ω- transaminases or by a single enzyme possessing low stereoselectivity. To tune the system ...