Design and synthesis of new (E)-cinnamic N-acylhydrazones as potent antitrypanosomal agents

…, SMSV Wardell, GHG Trossini, AD Andricopulo…

Index: Carvalho, Samir A.; Feitosa, Larisse O.; Soares, Marcio; Costa, Thadeu E.M.M.; Henriques, Maria G.; Salomao, Kelly; De Castro, Solange L.; Kaiser, Marcel; Brun, Reto; Wardell, James L.; Wardell, Solange M.S.V.; Trossini, Gustavo H.G.; Andricopulo, Adriano D.; Da Silva, Edson F.; Fraga, Carlos A.M. European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 512 - 521

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Citation Number: 20

Abstract

We report herein the synthesis and trypanocidal profile of new (E)-cinnamic N- acylhydrazones (NAHs) designed by exploiting molecular hybridization between the potent cruzain inhibitors (E)-1-(benzo [d][1, 3] dioxol-5-yl)-3-(4-bromophenyl) prop-2-en-1-one and (E)-3-hydroxy-N′-((2-hydroxynaphthalen-1-yl) methylene)-7-methoxy-2-naphthohydrazide. These derivatives were evaluated against both amastigote and trypomastigote forms of ...